Nu Instruments | Optimising Single Particle Nanoparticle Analysis with Vitesse TOF-ICP-MS
This application note explains how instrument tuning, reaction cell optimisation and advanced signal processing improve the quality of single particle ICP-MS measurements. It highlights practical workflows for identifying genuine particle events, reducing false positives and improving confidence in nanoparticle composition data.
Accurate nanoparticle analysis depends on more than high-speed acquisition. Signal quality, particle identification and data filtering all play a critical role in producing reliable results. This note demonstrates how optimisation of reaction cell conditions can reduce signal broadening and improve peak quality.
Nu Quant software provides flexible tools for particle detection and isotope coincidence analysis. Researchers can tailor processing parameters for different elements and particle types while retaining the ability to reprocess data if required.
The application note also introduces quality-control metrics that help identify particle overlaps, false peaks and coincidence events. These tools support method development and help ensure robust reporting of nanoparticle measurements.
Key Takeaways:
- Optimises reaction cell performance for improved nanoparticle peak shapes.
- Provides advanced quality-control tools for particle validation.
- Enables flexible post-acquisition data review and reprocessing.
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