Nu Instruments | High Accuracy Sr Isotope Ratio Determination Through Kr Interference Removal
Strontium isotope ratios are widely used in geochemistry, provenance studies and age determinations. This application note demonstrates how the Sapphire Collision/Reaction Cell removes krypton interferences to deliver highly accurate and precise strontium isotope measurements from very small sample quantities.

Precise strontium isotope measurements are essential across a wide range of geological and environmental applications. Conventional MC-ICP-MS techniques can be affected by krypton interferences and background noise, reducing measurement accuracy.
Using a helium and oxygen gas mixture, the Sapphire Collision/Reaction Cell effectively suppresses krypton species while preserving mass-dependent isotope fractionation. This allows accurate correction of instrumental mass bias.
The study demonstrates TIMS-like measurement trueness with only 16.5 ng of strontium per analysis. Results confirm that the technique supports rapid, highly precise isotope ratio determination without compromising data quality.

Key Takeaways:
- Krypton interferences are effectively removed using He-O₂ collision cell conditions.
- High trueness comparable to multi-dynamic TIMS is achieved.
- Precise strontium isotope analysis is possible from very small sample quantities.
