Nu Instruments | Clumped Isotope Analysis with Purpose-Built Mass Spectrometry
This application note outlines the analytical challenges of clumped isotope measurement and explains how Nu Instruments systems address them. It focuses on baseline stability, high resolution and instrument designs optimised for rare isotopologue analysis.
Clumped isotope analysis places demanding requirements on mass spectrometers because the species of interest can be present at only a few hundred parts per million of the major ion beam. These measurements require excellent dynamic range, high sensitivity and control of isobaric interferences.
The document discusses how conventional instruments can suffer from non-uniform baselines caused by scattered electrons and ions. Nu Instruments addresses this through electrostatic analyser arrays after the collector slit, helping reject scattered background while allowing isotopologue beams to pass.
For high-resolution studies, the Panorama mass spectrometer uses Matsuda ESA-quadrupole magnet geometry to provide resolution beyond 40,000 with high transmission. The Aspect instrument offers an alternative platform using Zoom technology and full 20 kV acceleration for sensitivity.
Key Takeaways:
- Clumped isotope studies require high sensitivity, high resolution and stable baselines.
- Electrostatic analyser arrays help reduce scattered background around minor peaks.
- Panorama and Aspect provide purpose-built options for demanding isotope applications.
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